A clinical trial that showed that vitamin E slowed the improve of some consequences of Alzheimer's disease by about 7 months has been discounted by recent studies.
Another clinical trial is examining either vitamin E and/or selenium supplements can prevent Alzheimer's disease or the cognitive decline connected with the disease. Ongoing investigate and clinical observations engaging other antioxidants are being planned.
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Some studies that claimed hormone change therapy, Nsaids (nonsteroidal anti-inflammatory drugs) and antioxidant vitamins as promising treatments in preventing or slowing Alzheimer's disease indicate that they do not.
Qi Dai, M.D., Ph.D., Assistant professor of Medicine, conducts ongoing investigate on causative and inhibitive measures for Alzheimer's Disease. The investigate is supported by grants from the National Institutes of Health. Dai and his investigate team began to presume that perhaps someone else class of antioxidant chemicals, known as polyphenols, could play a role in preventing or slowing down of Alzheimer's disease.
Polyphenols are non-vitamin antioxidants tasteless in the diet and particularly abundant in teas, juices and wines. Polyphenols exist primarily in the skins and peels of fruits and vegetables. recent studies have shown that they expand maximum lifespan by 59 percent and delay age-dependent decay of cognitive doing in animal models.
Food sources rich in polyphenols contain onion, apple, tea, red wine, red grapes, grape juice, strawberries, raspberries, blueberries, cranberries, and definite nuts.
"Also, animal studies and cell culture studies confirmed that some polyphenols from juices showed a stronger neuroprotective ensue than antioxidant vitamins. So we are now looking at polyphenols," Dai said.
At the 2nd International discussion on Polyphenols and condition held at the University of California campus in Davis October 4-7, 2005, the condition effects of Polyphenols was discussed by a broad range of researchers and scientists. There were global representatives that attended to hear the scientific presentations and discussions on the condition effects of polyphenolics.
Some of the findings finished that there are clear effects of polyphenols on established surrogate markers of cardiovascular diseases. Also the discussions centered on the biological effects involved in the protective effects of polyphenols against cardiovascular diseases, on different body tissues, i.e., blood vessels, heart muscles, etc.
There was a clear consensus that antioxidant activity is not directly connected to any condition effects, but is simply a biomarker for the presence of polyphenolics, a label that can be confounded by constitutive antioxidants.
The useful effects of phenolics now appears to be its effects on cell signaling and any speakers made this point at the conference. Researchers called for a clear, clinical demonstration of a human condition advantage from polyphenolics.
Researches are conducting more clinical trials to check blood polyphenol levels to see if high polyphenols collate with low Alzheimer's risk.
Alzheimer's Risk And Polyphenols